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整合素α2重組兔單克隆抗體

產(chǎn)品貨號：

BN42140R
中文名稱：

整合素α2重組兔單克隆抗體
英文名稱：

Rabbit anti-Integrin alpha 2 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42140R-50ul

50ul

￥2020.00

交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF
BN42140R-100ul

100ul

￥3240.00

交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱	Integrin alpha 2
中文名稱	整合素α2重組兔單克隆抗體
別名	Integrin alpha 2; CD49b antigen; BR; CD 49b; CD49 antigen like family member B; CD49b; CD49b; Collagen receptor; DX5; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency, included; GPIa; HPA 5 included; HPA5 included; Itga2; Platelet alloantigen Br(a), included; Platelet antigen Br; Platelet glycoprotein GPIa; Platelet glycoprotein Ia; Platelet glycoprotein Ia/Iia; Platelet membrane glycoprotein Ia; Platelet receptor for collagen, deficiency of, included; Very late activation protein 2 receptor alpha 2 subunit; VLA 2 alpha chain; VLA 2; VLA 2 subunit alpha; VLA2 alpha chain; ITA2_HUMAN.
研究領(lǐng)域	腫瘤細胞生物細胞粘附分子
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	14D7
交叉反應	Human, Mouse, Rat,
產(chǎn)品應用	WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	127kDa
細胞定位	細胞膜
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	Recombinant human Integrin alpha 2:
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
產(chǎn)品介紹	Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. SWISS: P17301 Gene ID: 3673 Database links: Entrez Gene: 3673 Human Entrez Gene: 16398 Mouse Omim: 192974 Human SwissProt: P17301 Human SwissProt: Q62469 Mouse Unigene: 482077 Human Unigene: 5007 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.