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CD9重組兔單克隆抗體

產(chǎn)品貨號：

BN42118R
中文名稱：

CD9重組兔單克隆抗體
英文名稱：

Rabbit anti-CD9 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42118R-50ul

50ul

￥2020.00

交叉反應(yīng)：Mouse,Human(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,ELISA
BN42118R-100ul

100ul

￥3240.00

交叉反應(yīng)：Mouse,Human(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,ELISA

產(chǎn)品描述

英文名稱	CD9
中文名稱	CD9重組兔單克隆抗體
別名	Tetraspanin 29; 5H9; 5H9 antigen; Antigen defined by monoclonal; 602 29; Antigen defined by monoclonal; 60229; BA 2; BA2; BTCC 1; BTCC1; CD 9; CD9; CD9 antigen; CD9 antigen p24; CD9 molecule; CD9_HUMAN; Cell growth inhibiting gene 2 protein; Cell growth-inhibiting gene 2 protein; DRAP 27; DRAP27; GIG 2; GIG2; Growth inhibiting gene 2 protein; Leukocyte antigen MIC3; MIC 3; MIC3; Motility related protein; Motility-related protein; MRP 1; MRP-1; MRP1; p24; P24; p24 antigen; Tetraspanin 29; Tetraspanin-29; Tetraspanin29; Tspan 29; Tspan-29; Tspan29.
研究領(lǐng)域	腫瘤細胞生物免疫學(xué) 發(fā)育生物學(xué) 細胞表面分子
抗體來源	Rabbit
克隆類型	Monoclonal
克隆號	4C2
交叉反應(yīng)	Human, Mouse, (predicted: Rat, )
產(chǎn)品應(yīng)用	WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	25kDa
細胞定位	細胞膜
性狀	Lyophilized or Liquid
濃度	1mg/ml
免疫原	Recombinant human CD9 :
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
產(chǎn)品介紹	CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve. Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. Subunit: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed by a variety of hematopoietic and epithelial cells. Post-translational modifications: Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Similarity: Belongs to the tetraspanin (TM4SF) family. SWISS: P21926 Gene ID: 928 Database links: Entrez Gene: 928 Human Entrez Gene: 12527 Mouse Entrez Gene: 24936 Rat Omim: 143030 Human SwissProt: P21926 Human SwissProt: P40240 Mouse SwissProt: P40241 Rat Unigene: 114286 Human Unigene: 210676 Mouse Unigene: 404614 Mouse Unigene: 2091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD9是一種普遍存在于細胞膜表面屬于四跨膜超蛋白家族的細胞表面糖蛋白, 參與質(zhì)膜的融合過程，在細胞膜生物學(xué)中發(fā)揮重要作用。近年來經(jīng)研究發(fā)現(xiàn)，CD9與多種腫瘤轉(zhuǎn)移有關(guān)，故稱腫瘤轉(zhuǎn)移抑制基因亦稱抗腫瘤轉(zhuǎn)移基因。是一個新的腫瘤轉(zhuǎn)移抑制基因膜運動相關(guān)蛋白-1(CD9/MRP-1)，其分子功能還有待于進一步研究。CD9主要在早B細胞、活化T淋巴細胞、嗜酸性粒細胞、嗜堿性粒細胞和血小板表達。