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蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體

產(chǎn)品貨號：

BN42031M
中文名稱：

蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體
英文名稱：

Mouse anti-JAK1 Monoclonal antibody
品牌：

Biorigin

貨號

產(chǎn)品規(guī)格

售價

備注
BN42031M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF
BN42031M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱	JAK1
中文名稱	蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體
別名	JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; JAK1_HUMAN.
研究領(lǐng)域	腫瘤細(xì)胞生物免疫學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶
抗體來源	Mouse
克隆類型	Monoclonal
克隆號	9G7
交叉反應(yīng)	Human, (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	133kDa
細(xì)胞定位	細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human JAK1:
亞型	IgG
純化方法	affinity purified by Protein G
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. Subunit: Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB. Subcellular Location: Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 2 protein kinase domains. Contains 1 SH2 domain. SWISS: P23458 Gene ID: 3716 Database links: Entrez Gene: 395681 Chicken Entrez Gene: 3716 Human Entrez Gene: 16451 Mouse Entrez Gene: 397202 Pig Entrez Gene: 84598 Rat Omim: 147795 Human SwissProt: P23458 Human SwissProt: P52332 Mouse Unigene: 207538 Human Unigene: 289657 Mouse Unigene: 90191 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 激酶和磷酸酶（Kinases and Phosphatases）