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硫氧還蛋白單克隆抗體

產(chǎn)品貨號(hào)：

BN41421M
中文名稱：

硫氧還蛋白單克隆抗體
英文名稱：

Mouse anti-Trx-Tag Monoclonal antibody
品牌：

Biorigin

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BN41421M-100ul

100ul

￥1360.00

交叉反應(yīng)：Human,Pig,Species independent 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱	Trx-Tag
中文名稱	硫氧還蛋白單克隆抗體
別名	Thioredoxin; ADF; Surface associated sulphydryl protein; Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TXN protein; ADF; ATL derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; TRDX; TRX 1; TRX; TRX1; TXN; TXN; ATL derived factor; ATL-derived factor; THIO_HUMAN; zgc:92903; Trx-Tag.
產(chǎn)品類型	標(biāo)簽抗體
研究領(lǐng)域	腫瘤細(xì)胞生物信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子
抗體來源	Mouse
克隆類型	Monoclonal
克隆號(hào)	7G10
交叉反應(yīng)	Recombinant protein
產(chǎn)品應(yīng)用	WB=1:1000-5000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	12kDa
細(xì)胞定位	細(xì)胞核細(xì)胞漿分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human Thioredoxin:
亞型	IgG
純化方法	affinity purified by Protein G
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Subunit: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner. Subcellular Location: Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Similarity: Belongs to the thioredoxin family. Contains 1 thioredoxin domain. SWISS: P10599 Gene ID: 7295 Database links: Entrez Gene: 7295 Human Entrez Gene: 22166 Mouse Entrez Gene: 116484 Rat Omim: 187700 Human SwissProt: P10599 Human SwissProt: P10639 Mouse SwissProt: P11232 Rat Unigene: 435136 Human Unigene: 260618 Mouse Unigene: 29777 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.