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產(chǎn)品規(guī)格
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BN40974R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN40974R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | CHRDL2 |
| 中文名稱 | 乳腺腫瘤新因子1抗體 |
| 別 名 | BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN. |
| 研究領域 | 腫瘤 免疫學 生長因子和激素 血管內皮細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Cow, Sheep, ) |
| 產(chǎn)品應用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CHRDL2:351-429/429 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors. Function: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. Subunit: Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA. Subcellular Location: Isoform 1: Secreted (Potential). Isoform 2: Secreted (Potential). Isoform 3: Cytoplasm (Potential). Isoform 4: Cytoplasm (Potential). Isoform 5: Cytoplasm (Potential). Tissue Specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma. Post-translational modifications: Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402. Similarity: Contains 3 VWFC domains. SWISS: Q6WN34 Gene ID: 25884 Database links: Entrez Gene: 25884 Human Omim: 613127 Human SwissProt: Q6WN34 Human Unigene: 432379 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CHRDL2原來主要用于乳腺癌的研究，近年來研究發(fā)現(xiàn)在腫瘤中也有發(fā)現(xiàn)，目前在肺癌，結腸腫瘤的研究中應用較多。 |
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